Article

Thymosin β4 is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis

2021-07-09

Abstract excerpt

Thymosin β4 (Tβ4) was extracted forty years ago 1 from calf thymus. Since then, it has been identified as a G-actin binding protein involved in blood clothing, tissue regeneration, angiogenesis, and anti-inflammatory processes. Tβ4 has also been implicated in tumor metastasis and neurodegeneration. However, the precise roles and mechanism(s) of action of Tβ4 in these processes remain largely unknown, with the bind...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 956a99a9-47f1-52e7-b054-2c263f546de7
DOI: 10.21203/rs.3.rs-677051/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Thymosin β4 is an Endogenous Iron Chelator and Molecular Switcher of FerroptosisDOI 10.21203/rs.3.rs-677051/v1Read

The Balance between Life and Death of Cells: Roles of MetallothioneinsSemantic proximity Read

A novel SOD1-dependent mechanism for the iron-induced production of toxic SOD1 and oxidative stress that initiates ALSSemantic proximity Read

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate BioengineeringSemantic proximity Read

Innovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-mycSemantic proximity Read

Terahertz Wave Desensitizes Ferroptosis by Inhibiting the Binding of Ferric Ions to the TransferrinSemantic proximity Read

The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and CancerSemantic proximity Read

Novel insights on targeting ferroptosis in cancer therapySemantic proximity Read

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammationSemantic proximity Read