Article

SOX2 and SOX9 as Transcriptional Regulators of human Galectin-3 in SW1353 Cells: Potential Implications for Osteoarthritis

2025-06-05

Abstract excerpt

Galectin-3 (Gal-3), a member of the β-galactoside-binding protein family, is critically involved in inflammation, extracellular matrix remodelling, and cartilage degeneration in osteoarthritis (OA). This study aims to elucidate the regulation of the human galectin-3 gene ( LGALS3 ) promoter in SW1353 cells and its control by SOX transcription factors, known to be dysregulated during OA pathogenesis. We sought to...

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Literature Corpus work: 94e04325-ab52-58e3-b0bd-cbda02516b3e
DOI: 10.1101/2025.06.03.657610

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