Article

Bromhexine Prophylaxis and Pharmacologically Attenuated Natural Immunization: A New Paradigm of Host-Directed Modulation of SARS-CoV-2 and Influenza Virus Infections

2026-08-12

Abstract excerpt

<h4>Background: </h4> Bromhexine hydrochloride (BRH) is a functional inhibitor of the host serine protease TMPRSS2, a key mediator of viral entry for SARS-CoV-2, influenza A and B viruses, and other respiratory viruses that utilize TMPRSS2-mediated proteolytic activation. While most antiviral strategies aim to prevent infection or suppress viral replication, partial modulation of host-dependent viral entry may rep...

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Literature Corpus work: 9479f021-d842-5424-8799-1ed169aac7ac
DOI: 10.20944/preprints202608.0777.v1

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