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Article

The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly.

Biology open - 15 Oct 2021

Zur Lage Petra, Xi Zhiyan, Lennon Jennifer, Hunter Iain, Chan Wai Kit, Bolado Carrancio Alfonso, von Kriegsheim Alex, Jarman Andrew P

Abstract excerpt

Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD). Studies in Drosophila have helped to validate several PCD genes whose products are required for cytoplasmic pre-assembly of axonemal dynein motors. Here we report the characterisation of the...

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Identifiers

PMID: 34553759
DOI: 10.1242/bio.058812
PMCID: PMC8565470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly.PMID 34553759Read ↗

The <i>Drosophila</i> orthologue of the primary ciliary dyskinesia-associated gene, <i>DNAAF3</i> , is required for axonemal dynein assemblySemantic proximity Read ↗

Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.Semantic proximity Read ↗

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Mutations in GAS8, a Gene Encoding a Nexin-Dynein Regulatory Complex Subunit, Cause Primary Ciliary Dyskinesia with Axonemal Disorganization.Semantic proximity Read ↗

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Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia.Semantic proximity Read ↗

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