Article

ATM inhibition enhance antitumor immunity of CRC by activating cGAS/STING and NFκB/IRF1/NLRC5 pathway

2024-03-27

Abstract excerpt

Backgroud Accumulating evidence supports the concept that DNA damage response (DDR) targeted therapies can improve antitumor immune response by increasing the immunogenicity of tumor cells and improving the tumor immune microenvironment. Ataxia telangiectasia mutated (ATM) is a core component of the DNA repair system. Although ATM gene has a significant mutation rate in many human cancers including colorectal, pr...

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Literature Corpus work: 93c6d072-a388-5547-acb1-a4c0fbf141a9
DOI: 10.21203/rs.3.rs-4116540/v1

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