Global gene repression by Dicer-independent tRNA Fragments

Abstract excerpt

tRNA derived RNA fragments (tRFs) is an emerging group of small RNAs as abundant as miRNAs, and yet their roles are not well understood. Here, we focus on endogenous tRFs (18-22 bases) derived from 3’ end of human mature tRNAs (tRF-3) and their functions in gene repression. tRF-3 levels increase upon parental tRNA over-expression or tRNA induction by c-Myc oncogene activation. Elevated tRF-3 levels lead to repress...

Topics

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• Cancer-related gene regulation
• Cancer-related molecular mechanisms research
• Cardiac Structural Anomalies and Repair
• Peptidase Inhibition and Analysis
• Respiratory viral infections research
• RNA and protein synthesis mechanisms
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

937c11ce-6e0a-5753-8e77-a7c0c6fbaa37

DOI

10.1101/143974