Article

Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses

2026-01-21

Abstract excerpt

Sialic acids (SAs) are abundantly expressed on vertebrate cell surfaces and are widely recognized as key viral attachment factors, particularly for influenza viruses. However, their role remains understudied in other orthomyxoviruses, such as thogoto and quaranja viruses, which are tick-borne viruses sporadically infecting humans. Enzymatic removal of SAs increased the infectivity of Thogoto and Dhori viruses, as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9327a057-f5a4-5df0-b85b-181da1f59126
DOI: 10.64898/2026.01.15.699645

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sialic acids are a barrier to the entry of non-influenza orthomyxovirusesDOI 10.64898/2026.01.15.699645Read

Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus SpilloverSemantic proximity Read

Sialobiology of Influenza: Molecular Mechanism of Host Range Variation of Influenza VirusesSemantic proximity Read

Avian Influenza Viruses Infect Primary Human Bronchial Epithelial Cells Unconstrained by Sialic Acid α2,3 ResiduesSemantic proximity Read

Sialic acid receptors: focus on their role in influenza infectionSemantic proximity Read

Sialic Acids as Receptors for PathogensSemantic proximity Read

Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin.Semantic proximity Read

Avian influenza and sialic acid receptors: more than meets the eye?Semantic proximity Read

Receptor Binding Properties of Neuraminidase for influenza A virus: An Overview of Recent Research AdvancesSemantic proximity Read

Gradual adaptation of animal influenza A viruses to human-type sialic acid receptorsSemantic proximity Read

Accumulated metagenomic studies reveal recent migration, whole genome evolution, and undiscovered diversity of orthomyxovirusesSemantic proximity Read

Virus versus host: influenza A virus circumvents the immune responsesSemantic proximity Read

Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.Semantic proximity Read