Article

Spectral sparsification helps restore the spatial structure at single-cell resolution

2022-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell RNA sequencing thoroughly quantifies the individual cell transcriptomes but renounces the spatial structure. Conversely, recently emerged spatial transcriptomics technologies capture the cellular spatial structure but skimp cell or gene resolutions. Cell-cell affinity estimated by ligand-receptor interactions can partially reconstruct the quasi-structure of cells but falsely include...

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Literature Corpus work: 92a4d43e-35be-5018-a181-f2e5510ca836
DOI: 10.1101/2022.01.25.477389

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