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Article

Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly.

Cell research - 1 Sept 2020

Ren Xianwen, Zhong Guojie, Zhang Qiming, Zhang Lei, Sun Yujie, Zhang Zemin

Abstract excerpt

Single-cell RNA sequencing (scRNA-seq) has revolutionized transcriptomic studies by providing unprecedented cellular and molecular throughputs, but spatial information of individual cells is lost during tissue dissociation. While imaging-based technologies such as in situ sequencing show great promise, technical difficulties currently limit their wide usage. Here we hypothesize that cellular spatial organization...

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Identifiers

PMID: 32541867
DOI: 10.1038/s41422-020-0353-2
PMCID: PMC7608415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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