Article

Targeted and efficient AAV therapy for neuroblastoma via direct capsid-antibody coupling

2025-11-13

Abstract excerpt

Adeno-associated viral (AAV) vectors are widely used in gene therapy for their versatility and safety, but their broad tropism limits cell-specific applications such as targeting primary or metastatic tumor cells. To address this, we developed AAV-STITCH, a strategy using SpyTag technology to covalently attach polypeptides to the AAV capsid. This allows precise, dose-dependent coupling of an anti-GD2 ScFv to a gal...

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Literature Corpus work: 91163d74-739b-59c4-bd65-65da55a26034
DOI: 10.1101/2025.11.12.687993

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