Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerged N193S mutation of PA-X protein disabled the immunity of mucosal dendritic cells for regulating virulence of clade 2.3.4.4b H5 subtype virus.

Emerging microbes & infections - 1 Dec 2026

Miao Xinyu, Xu Xing, Han Yixuan, Wang Yiling, Wang Wenqing, Wang Jinyuan, Yin Yuncong, Chen Sujuan, Peng Daxin, Qin Tao

Abstract excerpt

In recent years, H5 subtype highly pathogenic avian influenza viruses (HPAIVs), especially clade 2.3.4.4b, have posed a global threat to poultry, cattle, and public health. Bioinformatics analysis of H5 subtype AIVs from 2000 to 2023 revealed a progressive increase in the PA-X N193S mutation, which became predominant in both avian and mammalian isolates of clade 2.3.4.4b. Using reverse genetics, we generated...

Topics

Join the communities discussing this publication.

Dendritic Cells
Dogs
Influenza A virus
Influenza in Birds
Orthomyxoviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 42419306
DOI: 10.1080/22221751.2026.2695530
PMCID: PMC13353401

Genes

CCL5
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerged N193S mutation of PA-X protein disabled the immunity of mucosal dendritic cells for regulating virulence of clade 2.3.4.4b H5 subtype virus.PMID 42419306Read ↗

A single PA-X mutation in bovine-origin H5N1 influenza virus reduces pathogenicity in miceSemantic proximity Read ↗

PA-X I94V mutation modulates the pathogenicity of the highly pathogenic H7N9 influenza A virus in mice and chickens.Semantic proximity Read ↗

PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammalsSemantic proximity Read ↗

Dual effects of influenza A virus PA-X on suppression of cytokine signaling and MHC I pathway disruption in the human airway epitheliumSemantic proximity Read ↗

Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicitySemantic proximity Read ↗

PA and PA-X: two key proteins from segment 3 of the influenza virusesSemantic proximity Read ↗

The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickensSemantic proximity Read ↗

PA-X: a key regulator of influenza A virus pathogenicity and host immune responsesSemantic proximity Read ↗

Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in HumansSemantic proximity Read ↗

Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses.Semantic proximity Read ↗

Amino acid mutations PB1-V719M and PA-N444D combined with PB2-627K contribute to the pathogenicity of H7N9 in mice.Semantic proximity Read ↗

Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.