Article

Big DNA as a tool to dissect an age-related macular degeneration-associated haplotype

2018-11-04

Abstract excerpt

Age-related Macular Degeneration (AMD) is a leading cause of blindness in the developed world, especially in aging populations, and is therefore an important target for new therapeutic development. Recently, there have been several studies demonstrating strong associations between AMD and sites of heritable genetic variation at multiple loci, including a highly significant association at 10q26. The 10q26 risk regi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 910fd2f3-2520-53f2-aa33-f9b1af55e51a
DOI: 10.1101/461251

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Big DNA as a tool to dissect an age-related macular degeneration-associated haplotypeDOI 10.1101/461251Read

Transcriptome-wide association implicates <i>HTRA1-AS1</i> in age-related macular degeneration riskSemantic proximity Read

Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular DegenerationSemantic proximity Read

Targeted adaptive long-read sequencing for discovery of complex phased variants in inherited retinal disease patients.Semantic proximity Read

Application and interpretation of genome-wide association (GWA) studies for informing pharmacogenomic research - examples from the field of age-related macular degeneration.Semantic proximity Read

A systems biology approach uncovers novel disease mechanisms in age-related macular degenerationSemantic proximity Read

10q26 - The enigma in age-related macular degeneration.Semantic proximity Read

Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?Semantic proximity Read

Bringing the age-related macular degeneration high-risk allele age-related maculopathy susceptibility 2 into focus with stem cell technology.Semantic proximity Read

Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26.Semantic proximity Read

Using single molecule Molecular Inversion Probes as a cost-effective, high-throughput sequencing approach to target all genes and loci associated with macular diseasesSemantic proximity Read

Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines.Semantic proximity Read

A Fosmid Pool-Based Next Generation Sequencing Approach to Haplotype-Resolve Whole Genomes.Semantic proximity Read