Article

Human iPS Cells Derived Skeletal Muscle Progenitor Cells Promote Myoangiogenesis and Restore Dystrophin in Duchenne Muscular Dystrophic Mice

2020-01-21

Abstract excerpt

<h4>Background and Objective</h4> Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. Loss of dystrophin leads to severe and progressive muscle-wasting in both skeletal and heart muscles. Human induced pluripotent stem cells (hiPSCs) and their derivatives offer important opportunities to treat a number of diseases. Here, we investigated whether givinostat, a h...

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Literature Corpus work: 9045813f-3a75-5aca-be56-bc8d41d4ab3d
DOI: 10.1101/2020.01.21.914283

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