Article
Rapid detection of mutations in the suspected piperaquine resistance gene E415G-exo in Plasmodium falciparum exonuclease via AS‒PCR and RAA with CRISPR/Cas12a.
International journal for parasitology. Drugs and drug resistance - 1 Dec 2024
Zhu Huiyin, Zhu Daiqian, Li Yuting, Li Yun, Song Xiaonan, Mo Jinyu, Liu Long, Liu Zhixin, Wang Siqi, Yao Yi, Yan He, Wu Kai, Wang Wei, Yin Jianhai, Lin Min, Li Jian
Abstract excerpt
Malaria remains a major public health concern. The rapid spread of resistance to antimalarial drugs is a major challenge for malaria eradication. Timely and accurate molecular monitoring based on practical detection methods is a critical step toward malaria control and elimination. In this study, two rapid detection techniques, allele-specific PCR (AS‒PCR) and recombinase-aided amplification (RAA) combined with...
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