Article

Direction-specific excitation-inhibition imbalances and their neurobiological substrates in recurrent major depressive disorder

2026-05-21

Abstract excerpt

<h4>Background</h4> Major depressive disorder (MDD) is characterized by disrupted information flow among brain regions. While effective connectivity (EC) captures these causal interactions, the underlying structural and molecular basis remain unclear. This study aims to investigate direction-specific EC alterations in MDD and their associations with laminar structural covariance (SC) and transcriptional and neuro...

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Literature Corpus work: 8fc91a17-6731-5522-accc-af768d92006e
DOI: 10.64898/2026.05.17.26351714

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