Article

Potentially repurposable drugs for schizophrenia identified from its interactome

2018-10-13

Abstract excerpt

From the schizophrenia drug-target interactome, 1 we studied the drugs that targeted multiple proteins in the interactome, or those that target proteins with many targets, or those that target novel (computationally predicted) interactors of schizophrenia associated proteins. In schizophrenia, gene expression has been described as a measurable aspect of the disease reflecting the action of risk genes. We studied...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 53ee7acd-4164-545e-bd25-41ba7768f3a4
DOI: 10.1101/442640

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Potentially repurposable drugs for schizophrenia identified from its interactomeDOI 10.1101/442640Read

Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia.Semantic proximity Read

Candidates for Drug Repurposing to Address the Cognitive Symptoms in SchizophreniaSemantic proximity Read

Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia.Semantic proximity Read

When GWAS meets the Connectivity Map: drug repositioning for seven psychiatric disordersSemantic proximity Read

Uncovering novel therapeutics for schizophrenia: a multitarget approach using the CANDO platformSemantic proximity Read

[Approach for identifying novel drug targets of schizophrenia].Semantic proximity Read

Pathway and network embedding methods for prioritizing psychiatric drugsSemantic proximity Read

Using genome-wide association results to identify drug repurposing candidatesSemantic proximity Read

Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds.Semantic proximity Read

PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery.Semantic proximity Read

Integrative Omics for Informed Drug Repurposing: Targeting CNS DisordersSemantic proximity Read

Pharmacologic and genetic evidence converge on mechanisms of psychotic illnessSemantic proximity Read