Article

Clinical Response to Azacitidine in Myelodysplastic Neoplasms is Associated with Distinct DNA Methylation Changes in Haematopoietic Stem and Progenitor cells<i>in vivo</i>

2024-07-23

Abstract excerpt

Hypomethylating agents are used as frontline therapy for myelodysplastic neoplasms (MDS), but clinical response is unpredictable. To determine whether response was associated with in vivo dynamics of DNA hypomethylation, we conducted a phase 2 trial for MDS using both injection and oral azacitidine (AZA). We established that global DNA methylation levels in peripheral blood and bone marrow mononuclear cells were c...

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Literature Corpus work: 8edabe40-10b4-5608-b226-c6a8a13b111e
DOI: 10.1101/2024.07.19.24310679

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