Optimizing the Treatment of Acute Promyelocytic Leukemia: A Maintenance-Free Strategy for Complete Remission

Abstract excerpt

<h4>Background: </h4> Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML), comprising 5–10% of all AML cases. Characterized by the t(15;17) chromosomal translocation, APL presents a unique challenge due to its associated bleeding manifestations and coagulopathy, emphasizing the need for urgent and specialized management. <h4>Methods:</h4> This prospective open-label pilot study...

Topics

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• Arsenic Trioxide
• Drug Resistance, Neoplasm
• fms-Like Tyrosine Kinase 3
• Leukemia, Promyelocytic, Acute
• Leukocyte Count
• Retinoids in leukemia and cellular processes
• Risk Factors
• Tretinoin

Identifiers and source

Literature Corpus work

8ed3b046-d252-5fa4-8d8a-e2d54eed5783

DOI

10.21203/rs.3.rs-4204216/v1