Reversing Nicotine Toxicity: how Platelet-Rich Plasma Enhances Cell Recovery through Autophagy Modulation

Abstract excerpt

<h4>Background</h4> Chronic exposure to nicotine significantly exacerbates periodontitis, a prevalent inflammatory disease, by inducing cellular processes such as autophagy and inflammation in gingival fibroblasts. Current therapies often fail to fully address these cellular alterations in smokers, highlighting a need for innovative therapeutic and generative approaches. <h4>Objective</h4> This study explores th...

Topics

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• Antimicrobial Peptides and Activities
• Autophagy in Disease and Therapy
• Dietary Effects on Health
• Genetics, Aging, and Longevity in Model Organisms
• Heme Oxygenase-1 and Carbon Monoxide
• Neuroinflammation and Neurodegeneration Mechanisms
• Oral microbiology and periodontitis research
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

8e7a4f6e-90c4-56ea-977a-4f02f6cf605b

DOI

10.1101/2025.10.06.680686