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Article

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

Development (Cambridge, England) - 5 Nov 2019

Oleari Roberto, Caramello Alessia, Campinoti Sara, Lettieri Antonella, Ioannou Elena, Paganoni Alyssa, Fantin Alessandro, Cariboni Anna, Ruhrberg Christiana

Abstract excerpt

Gonadotropin-releasing hormone (GnRH) neurons regulate puberty onset and sexual reproduction by secreting GnRH to activate and maintain the hypothalamic-pituitary-gonadal axis. During embryonic development, GnRH neurons migrate along olfactory and vomeronasal axons through the nose into the brain, where they project to the median eminence to release GnRH. The secreted glycoprotein SEMA3A binds its receptors...

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Identifiers

PMID: 31690636
DOI: 10.1242/dev.176461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.PMID 31690636Read ↗

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