Article

Inactivating PLEKHA6 Mutations Cause Idiopathic Hypogonadotropic Hypogonadism Through Impaired Kisspeptin Secretion

2026-04-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Idiopathic hypogonadotropic hypogonadism (IHH) is characterized by impaired reproductive maturation, and approximately half of all cases lack an identified genetic cause. We investigated the genetic basis of IHH in two large cohorts to identify novel disease-causing genes. <h4>Methods</h4> We analyzed exome and genome sequencing data from 1,822 patients with IHH from two indep...

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Literature Corpus work: 3d36122c-9a4b-5404-afea-7caf6d185ad9
DOI: 10.64898/2026.04.10.26349358

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