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Article

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance

2026-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Cortical expansion in the human lineage was accompanied by alterations in cortical circuit architecture, including an elaboration of cortico-cortical connectivity. Yet how these changes reshape network computation to support behavior remains poorly understood. Here we leverage a mouse model expressing SRGAP2C , a human-specific gene duplication that modifies cortical circuit development and inc...

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Literature Corpus work
8e4a8b6f-f895-5e03-b0d6-b3ffb7ff79d6
DOI
10.64898/2026.06.24.734394
Open publication

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A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performanceDOI 10.64898/2026.06.24.734394
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