Article

TNF-α induces reactivation of human cytomegalovirus independently of myeloid cell differentiation following post-transcriptional establishment of latency

2018-04-10

Abstract excerpt

<h4>ABSTRACT</h4> We used the Kasumi-3 model to study HCMV latency and reactivation in myeloid progenitor cells. Kasumi-3 cells were infected with HCMV strain TB40/E wt -GFP, flow sorted for GFP+ cells, and cultured for various times to monitor establishment of latency, as judged by repression of viral gene expression (RNA/DNA ratio) and loss of virus production. We found that, in the vast majority of cells, lat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d1007b1-c6f9-5bef-ade0-04b376aa9dcd
DOI: 10.1101/298547

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TNF-α induces reactivation of human cytomegalovirus independently of myeloid cell differentiation following post-transcriptional establishment of latencyDOI 10.1101/298547Read

Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of LatencySemantic proximity Read

A Myeloid Progenitor Cell Line Capable of Supporting Human Cytomegalovirus Latency and Reactivation, Resulting in Infectious ProgenySemantic proximity Read

Latency and reactivation of human cytomegalovirusSemantic proximity Read

Alternative Promoters Drive Human Cytomegalovirus Reactivation from LatencySemantic proximity Read

Cytomegalovirus latency and reactivation: recent insights into an age old problemSemantic proximity Read

Advances in Model Systems for Human Cytomegalovirus Latency and ReactivationSemantic proximity Read

Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latencySemantic proximity Read

Role for Tumor Necrosis Factor Alpha in Murine Cytomegalovirus Transcriptional Reactivation in Latently Infected LungsSemantic proximity Read

Viral gene expression during the establishment of human cytomegalovirus latent infection in myeloid progenitor cellsSemantic proximity Read

Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and ReactivationSemantic proximity Read

Epigenetic Reprogramming of Host and Viral Genes by Human Cytomegalovirus Infection in Kasumi-3 Myeloid Progenitor Cells at Early Times PostinfectionSemantic proximity Read

Myeloblastic Cell Lines Mimic Some but Not All Aspects of Human Cytomegalovirus Experimental Latency Defined in Primary CD34+Cell PopulationsSemantic proximity Read