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ATF3-induced activation of the NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma

2023-07-25

Abstract excerpt

<h4>Purpose: </h4> Olaparib, an inhibitor of poly-(adenosine diphosphate-ribose) polymerase (PARP), has been shown to have anticancer benefits in patients with pancreatic cancer who have a germline mutation in BRCA1/2. However, resistance acquired on long-term exposure to olaparib significantly impedes clinical efficacy. Methods In this study, the chromatin accessibility and differentially expressed transcripts o...

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Literature Corpus work
8c8944c0-f24c-53e9-a12a-ad45cbca58f4
DOI
10.21203/rs.3.rs-3172142/v1
Open publication

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ATF3-induced activation of the NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinomaDOI 10.21203/rs.3.rs-3172142/v1
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