Back to search

Article

Hyperhomocysteinemia-Induced miR-30d-5p Regulates TIMP3 and MMP9, Enhancing Atherosclerosis Progression

2025-05-22

Abstract excerpt

<title>Abstract</title> <p><bold>Background and Aims:</bold> Elevated homocysteine (Hcy) levels are a risk factor for cardiovascular diseases, including atherosclerosis. MicroRNAs (miRNAs) influence genes linked to atherosclerosis, but their role in hyperhomocysteinemia (HHcy) remains unclear. miR-30d-5p is up-regulated in the plasma of patients with HHcy and deep venous thrombosis (DVT), with TIMP3 identified as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8bfa9a55-8aa1-547b-a97a-30914b1a45d2
DOI
10.21203/rs.3.rs-6674730/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hyperhomocysteinemia-Induced miR-30d-5p Regulates TIMP3 and MMP9, Enhancing Atherosclerosis ProgressionDOI 10.21203/rs.3.rs-6674730/v1
Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular DiseaseSemantic proximity
Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular PathologySemantic proximity
miR‐195‐3p alleviates homocysteine‐mediated atherosclerosis by targeting IL‐31 through its epigenetics modificationsSemantic proximity
Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated AtherosclerosisSemantic proximity
Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms.Semantic proximity
Homocysteine Metabolites Impair the PHF8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and MiceSemantic proximity
Transfer of exosomal microRNA-203-3p from dendritic cells to bone marrow-derived macrophages reduces development of atherosclerosis by downregulating Ctss in mice.Semantic proximity
Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease.Semantic proximity
MiR-202-3p Inhibits Foam Cell Formation and is Associated with Coronary Heart Disease Risk in a Chinese Population.Semantic proximity
Homocysteine Metabolites Impair the Phf8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of PHF8-targeting miR-22-3p and miR-1229-3p in Human Vascular Endothelial CellsSemantic proximity
Dietary Shift Leads to Venous Thrombosis-Induced Congestive Liver Failure in CBS-Deficient Mice.Semantic proximity
Exosomal miR-320e is a potential target of CVSD that regulates the Wnt2-mediated Wnt/β-catenin signaling pathwaySemantic proximity
Select a neighboring publication to make it the new centre.