Article

Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brain

2020-07-30

Abstract excerpt

<h4>ABSTRACT</h4> The development of neuroinflammation, as well as the progression of several neurodegenerative diseases, has been associated with the activation and mobilization of the peripheral immune system due to systemic inflammation. However, the mechanism by which this occurs remains unclear. Herein, we addressed the effect of systemic, endotoxin-free induced-co-expression of IL-12 and IL-18 in the establ...

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Literature Corpus work: 8bd8ce05-48c8-53ed-88b7-241cd308e3f1
DOI: 10.1101/2020.07.30.228098

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Systemic sterile induced-co-expression of IL-12 and IL-18 drives IFN-γ-dependent activation of microglia and recruitment of MHC-II-expressing inflammatory monocytes into the brainDOI 10.1101/2020.07.30.228098Read

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