Article

Proteomic and Crotonylomic Integration of a Self-Established IgA Nephropathy Cohort Reveals Dysregulated Secretory Proteins and Immune Cell Regulators

2025-11-11

Abstract excerpt

<title>Abstract</title> <p>Background Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with 20–40% of patients progressing to end-stage renal disease. However, the molecular mechanisms linking peripheral immune dysregulation to local renal injury-particularly the regulatory patterns and post-translational modifications (PTMs) of secreted proteins-remain largely unexp...

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Literature Corpus work: 8bc69c77-b7f1-5d51-8fc0-2042d917fb3c
DOI: 10.21203/rs.3.rs-7901738/v1

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