Article

Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein Filamin

2000-10-01

Abstract excerpt

The human androgen receptor (hAR) is a ligand-dependent transcription factor responsible for the development of the male phenotype. The mechanism whereby nuclear translocation of the hAR is induced by its natural ligand 5α-dihydrotestosterone is a phenomenon not fully understood. The two-hybrid interaction trap assay has been used to isolate proteins that interact with the hAR in an attempt to identify molecules i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b715ff2-37f0-5ce5-b25a-fcfdd385783c
DOI: 10.1210/me.14.10.1618

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein FilaminDOI 10.1210/me.14.10.1618Read

Androgen Receptor Nuclear Translocation Is Facilitated by the f-Actin Cross-Linking Protein FilaminSemantic proximity Read

Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.Semantic proximity Read

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells.Semantic proximity Read

Extranuclear partners of androgen receptor: at the crossroads of proliferation, migration, and neuritogenesisSemantic proximity Read

Androgen-Induced Cell Migration: Role of Androgen Receptor/Filamin A AssociationSemantic proximity Read

Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cellsSemantic proximity Read

The fluorescent two-hybrid assay for live-cell profiling of androgen receptor modulators.Semantic proximity Read

The Androgen Receptor Interacts with Multiple Regions of the Large Subunit of General Transcription Factor TFIIFSemantic proximity Read

Identification of a Hormone-regulated Dynamic Nuclear Actin Network Associated with Estrogen Receptor α in Human Breast Cancer Cell NucleiSemantic proximity Read

Ligand-Specific Dynamics of the Androgen Receptor at Its Response Element in Living CellsSemantic proximity Read

Impaired nuclear translocation, nuclear matrix targeting, and intranuclear mobility of mutant androgen receptors carrying amino acid substitutions in the deoxyribonucleic acid-binding domain derived from androgen insensitivity syndrome patients.Semantic proximity Read

A Cellular Conformation-Based Screen for Androgen Receptor InhibitorsSemantic proximity Read