Article

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

2023-12-21

Abstract excerpt

<h4>ABSTRACT</h4> BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and cytotoxic T-cells, respectively. Our single-center data suggested that variability in Vp1 and LTag may contribute to failing BKPyV-specific imm...

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Literature Corpus work: 8b093d58-30eb-50b6-87d4-1c3e1fcae0ac
DOI: 10.1101/2023.12.21.572635

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