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SARS-CoV-2 within-host and in-vitro genomic variability and sub-genomic RNA levels indicate differences in viral expression between clinical and in-vitro cohorts

2021-11-24

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<h4>Background</h4> Low frequency intrahost single nucleotide variants (iSNVs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been increasingly recognised as predictive indicators of positive selection. Particularly as growing numbers of SARS-CoV-2 variants of interest (VOI) and concern (VOC) emerge. However, the dynamics of subgenomic RNA (sgRNA) expression and its impact on genomic diversit...

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Literature Corpus work: 8aa19da5-ff05-5cd7-8f16-287dc13ceb3a
DOI: 10.1101/2021.11.23.21266789

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SARS-CoV-2 within-host and <i>in-vitro</i> genomic variability and sub-genomic RNA levels indicate differences in viral expression between clinical and <i>in-vitro</i> cohorts

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