Back to search

Article

Intranasal Pediatric Parainfluenza Virus-Vectored SARS-CoV-2 Vaccine Candidate Is Protective in Macaques

2022-05-26

Abstract excerpt

Pediatric SARS-CoV-2 vaccines are needed that elicit immunity directly in the airways, as well as systemically. Building on pediatric parainfluenza virus vaccines in clinical development, we generated a live-attenuated parainfluenza virus-vectored vaccine candidate expressing SARS-CoV-2 prefusion-stabilized spike (S) protein (B/HPIV3/S-6P) and evaluated its immunogenicity and protective efficacy in rhesus macaques...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8a634c65-f5ae-56c8-ae05-fe7061fb9bf4
DOI
10.2139/ssrn.4120772
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Intranasal Pediatric Parainfluenza Virus-Vectored SARS-CoV-2 Vaccine Candidate Is Protective in MacaquesDOI 10.2139/ssrn.4120772
Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaquesSemantic proximity
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamstersSemantic proximity
An intranasal vaccine durably protects against SARS-CoV-2 variants in miceSemantic proximity
Protein Vaccine Induces a Durable, More Broadly Neutralizing Antibody Response in Macaques than Natural Infection with SARS-CoV-2 P.1Semantic proximity
Infants and young children generate more durable antibody responses to SARS-CoV-2 infection than adultsSemantic proximity
A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaquesSemantic proximity
Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2Semantic proximity
Differential Adaptive Immune Responses Following SARS-CoV-2 Infection in Children Compared to AdultsSemantic proximity
A Single Intranasal or Intramuscular Immunization with Chimpanzee Adenovirus Vectored SARS-CoV-2 Vaccine Protects Against Pneumonia in HamstersSemantic proximity
Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2Semantic proximity
Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primatesSemantic proximity
Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protectiveSemantic proximity
Select a neighboring publication to make it the new centre.