Article

Saturation genome editing of <i>BARD1</i> resolves VUS and provides insight into BRCA1-BARD1 tumor suppression

2025-11-06

Abstract excerpt

BARD1 encodes a dimeric partner of BRCA1 and is required for homology-directed double strand DNA break repair 1–5 . Germline loss-of-function variants in BARD1 are linked to elevated risk for breast cancer and neuroblastoma 6–8 and PARP inhibitors have shown effectiveness against BARD1-deficient tumors. However, the majority of BARD1 variants identified by genetic testing for cancer risk are variants of uncert...

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Literature Corpus work: 8a0660c2-f828-52fd-a85e-15be0e149fa0
DOI: 10.1101/2025.11.03.25339440

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