Article

Saturation Genome Editing reveals the functional impact of RAD51D <i>and</i> XRCC2 variants

2026-06-13

Abstract excerpt

Germline pathogenic variants in RAD51D and XRCC2 , which encode RAD51 paralogs that form a heterodimer within the BCDX2 complex, confer increased cancer risk and homologous recombination deficiency. However, most RAD51D and XRCC2 variants in ClinVar are classified as variants of uncertain significance (VUS), limiting clinical utility. Here, we applied saturation genome editing (SGE) to measure the effects of 5...

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Literature Corpus work: 75fc0a11-e2df-59d8-b9f3-275fd06c0e2a
DOI: 10.64898/2026.06.12.731983

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