Article

fourSynergy: Ensemble-based interaction calling on 4C-seq data using gradient-free optimization

2026-06-01

Abstract excerpt

<h4>Motivation</h4> Chromatin organization plays a crucial role in gene regulation and is associated with various severe diseases like cancer. Since chromatin changes are potentially reversible, a deeper understanding of the alterations needs to be harnessed for the development of new therapies. Circular Chromosome Conformation Capture Sequencing (4C-seq) is a sequencing technique enabling the identification of c...

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Literature Corpus work: 89bb1c02-ed6a-515e-b35e-f96a569c6296
DOI: 10.64898/2026.05.27.728108

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