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Antileishmanial Derivatives of Humulene from Asteriscus hierochunticus with in silico Tubulin Inhibition Potential

2021-06-21

Abstract excerpt

Two humulene derivatives (asteriscunolides A (1) and C (2)) were isolated from the methanolic extract of the whole plant of Asteriscus hierochunticus. Their structures were characterized by IR, 1D, and 2D NMR and HRESIMS data analysis, in addition to comparison with literature. Compounds 1 and 2 exhibited excellent in vitro antileishmanial activities against Leishmania donovani promastigotes with IC50 values of 8....

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Literature Corpus work
89639588-4a07-56b5-8538-07870d1906ea
DOI
10.25135/rnp.253.21.01.1945
Open publication

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