Article

Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding

2025-03-13

Abstract excerpt

Microtubules assemble from tubulin heterodimers composed of conserved α- and β- tubulins. In many species, including humans, tubulins are expressed from multiple genes. While the resulting tubulin isotypes–show only subtle sequence differences, microtubules made of distinct isotypes can differ in their dynamic behaviour, as well as in their structure, for example in the number of their protofilaments. In cells, tu...

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Literature Corpus work: 893c0983-6a7e-52a3-859d-8408b54630ed
DOI: 10.1101/2025.03.12.642813

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