Anti-diabetic effect of di-caffeoylquinic acid is associated with the modulation of gut microbiota and bile acid metabolism

Abstract excerpt

<title>Abstract</title><p>Background The human gut microbiome plays a critical role in both health and disease. A classic example of host-gut microbial co-metabolism involves bile acids, which biosynthesis in liver are excreted into the intestine where they are deconjugated and transformed by the gut microbiota, this process, in turn, activates signaling pathways, influencing host glycolipid and energy metabolism....

Topics

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• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Drug-Induced Hepatotoxicity and Protection
• Drug Transport and Resistance Mechanisms
• Gut microbiota and health
• Liver Disease Diagnosis and Treatment
• Pediatric Hepatobiliary Diseases and Treatments
• Phytochemicals and Antioxidant Activities

Identifiers and source

Literature Corpus work

88ae5c67-9da1-59d8-9905-54428ec28d7c

DOI

10.21203/rs.3.rs-3875238/v1