Article
ANGPTL6 Genetic Variants Are an Underlying Cause of Familial Intracranial Aneurysms.
Neurology - 9 Feb 2021
Hostettler Isabel C, O'Callaghan Benjamin, Bugiardini Enrico, O'Connor Emer, Vandrovcova Jana, Davagnanam Indran, Alg Varinder, Bonner Stephen, Walsh Daniel, Bulters Diederik, Kitchen Neil, Brown Martin M, Grieve Joan, Werring David J, Houlden Henry
Abstract excerpt
PURPOSE: To understand the role of the angiopoietin-like 6 gene (ANGPTL6) in intracranial aneurysms (IAs), we investigated its role in a large cohort of familial IAs. METHODS: Individuals with family history of IA were recruited to the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study. The ANGPTL6 gene was sequenced using Sanger sequencing. Identified genetic variants were compared to a control...
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