Article

From human joints to bioreactor setups: quantifying mechanical stimuli in cartilage physiology and regeneration

2025-10-06

Abstract excerpt

<h4>Objective</h4> Bioreactors are widely used to apply mechanical stimuli to osteochondral (OC) explants and cartilage tissue-engineered (TE) constructs, yet their ability to replicate native joint mechanics is not well quantified. This study benchmarks common bioreactor loading protocols against a finite element (FE) model of the human knee during gait, enabling direct comparison to physiologically relevant mec...

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Identifiers and source

Literature Corpus work: 885a97f6-442c-56dd-add3-495a850bb4ac
DOI: 10.1101/2025.10.06.678667

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