Article

STING–STAT3–SOX18 Axis Drives EndMT and Epigenetic Reprogramming in SAVI Lung Fibrosis

2026-03-24

Abstract excerpt

<h4>ABSTRACT</h4> A high prevalence of early-onset interstitial lung disease, including pulmonary fibrosis, in pediatric patients with Stimulator of interferon genes (STING)-Associated Vasculopathy with onset in infancy (SAVI) suggests a critical role for the cGAS-STING pathway in the pathogenesis of pulmonary fibrosis. We identified an endothelial-to-mesenchymal transition (EndMT) signature in lesional lung biop...

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Literature Corpus work: 87badbaf-b4e7-5269-b36e-4150d28e4827
DOI: 10.64898/2026.03.23.713256

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