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Article

Interstitial lung disease and the STING pathway.

The Journal of clinical investigation - 1 Jun 2026

Velu Prasad Palani, Zhu Gaofeng, Mackenzie Karen J

Abstract excerpt

Identification of the genetic mutations underlying the ultrarare monogenic conditions STING-associated vasculopathy with onset in infancy (SAVI) and coatomer protein complex subunit alpha (COPA) syndrome revealed a role for the stimulator of interferon genes (STING) immune pathway in the pathogenesis of interstitial lung disease (ILD) in these conditions. STING-focused therapeutics could be a potential avenue for...

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Identifiers

PMID: 42222885
DOI: 10.1172/JCI204544
PMCID: PMC13221230

Genes

COPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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