Article

Tripleknock: predicting lethal effect of three-gene knockout in bacteria by deep learning

2025-08-02

Abstract excerpt

Investigating the lethal effect of multi-gene knockout is essential for discovering novel antibiotics targets and metabolic engineering. Unlike single genes or gene pairs, three-gene combinations involve more intricate interactions, making experimental screening time-consuming. Computational methods, particularly Genome-scale metabolic Model (GEM)-based Flux Balance Analysis (FBA), requires constructing new GEMs f...

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Literature Corpus work: 87766704-db7d-5ea9-ba79-b2cd86d59078
DOI: 10.1101/2025.07.31.667916

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