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Microbial Scl1 Activates TGFβR1 receptor kinase signalling to Drive Fibrosis – Inflammation Axis in Alcohol-Associated Liver Disease

2025-07-08

Abstract excerpt

<h4>Background and Aims</h4> Alcohol consumption alters gut microbiota, which can affect metabolism, immune regulation, and signalling pathways and lead to alcohol-associated liver disease (ALD). We investigated how alcohol-associated gut microbiota (AGMs) modulate liver kinome signalling to drive inflammation and fibrosis in ALD. <h4>Method</h4> Liver kinome and metaproteome changes were studied in rats (n=6/gr...

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Literature Corpus work
86bbb112-1444-59fa-92a2-1f7ae47d61ea
DOI
10.1101/2025.07.08.663677
Open publication

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Microbial Scl1 Activates TGFβR1 receptor kinase signalling to Drive Fibrosis – Inflammation Axis in Alcohol-Associated Liver DiseaseDOI 10.1101/2025.07.08.663677
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