Article

CRSwNP-derived cells retain native disease-relevant characteristics in vitro

2025-12-03

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective and design</bold> : Chronic rhinosinusitis (CRS) is a persistent inflammation of the paranasal sinuses, classified into CRSwNP and CRSsNP. CRSwNP is characterized by a type 2–driven immune response with elevated IL-4 and IL-13, epithelial barrier dysfunction and extracellular matrix deposition. Epithelium and fibroblasts contribute to the Th2 milieu. The aim of this s...

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Literature Corpus work: 865e0353-9102-5487-8f8b-b563b0855423
DOI: 10.21203/rs.3.rs-8223068/v1

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