Article

Detecting GPCR Complexes in Postmortem Human Brain with Proximity Ligation Assay and A Bayesian Classifier

2019-07-02

Abstract excerpt

Despite the general controversy regarding the existence and physiological relevance of Class A GPCR dimerization, there is substantial evidence for functional interactions between dopamine D2 receptor (D2R) and adenosine A2A receptor (A2AR). A2AR-D2R complexes have been detected in rodent brains by proximity ligation assay (PLA), but their existence in the human brain is yet to be demonstrated. In this study, we u...

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Literature Corpus work: 85e23f57-4446-5ea5-812f-fb80167411c2
DOI: 10.1101/687780

Open publication

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