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THR-6E: A Six-Gene Cell-of-Origin Signature Stratifies Risk and Predicts Systemic Therapy Response in ER+/HER2− Breast Cancer

2026-02-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Genomic assays such as Oncotype DX, MammaPrint, and Prosigna have transformed risk stratification and treatment selection in early-stage, estrogen receptor-positive (ER+), HER2-negative breast cancers by enabling more precise prognostication and chemotherapy de-escalation in selected patients. However, their clinical utility is limited in lymph nodes positive disease. A majo...

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Literature Corpus work: 85a54a9f-8130-5b69-94f1-e43a1801f06c
DOI: 10.64898/2026.01.31.26345244

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