Article

Serotonin signaling modulates growth and motility in juvenile <i>Fasciola hepatica</i>

2025-10-03

Abstract excerpt

Fasciola hepatica causes fasciolosis, a parasitic disease that poses significant animal and human health challenges. Control relies on flukicides, most of which are adulticides, with only triclabendazole effective against the pathogenic migratory juvenile. Classical neurotransmitter pathways are widely targeted by anthelmintics yet remain underexplored for flukicide development. Here we explore the importance of s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85954014-8ad1-5132-bea5-8c7c27ac64f8
DOI: 10.1101/2025.10.02.679961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Serotonin signaling modulates growth and motility in juvenile <i>Fasciola hepatica</i>DOI 10.1101/2025.10.02.679961Read

Transcriptomic analysis reveals a role for the nervous system in regulating growth and development of <i>Fasciola hepatica</i> juvenilesSemantic proximity Read

Profiling G protein-coupled receptors of <i>Fasciola hepatica</i> identifies orphan rhodopsins unique to phylum PlatyhelminthesSemantic proximity Read

Wnt/β-catenin signalling underpins juvenile <i>Fasciola hepatica</i> growth and developmentSemantic proximity Read

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodesSemantic proximity Read

A new semi-automated, motility-based screening assay for discovery of compounds with activity against the juvenile stage of <i>Fasciola hepatica</i>Semantic proximity Read

When offspring outsmarting parents: Neuronal genes expression in two generations of marine parasitic wormSemantic proximity Read

Calmodulin disruption impacts growth and motility in juvenile liver fluke.Semantic proximity Read

Polo-like kinase 1 regulates growth in juvenile <i>Fasciola hepatica</i>Semantic proximity Read

Stimulating Neoblast-Like Cell Proliferation in Juvenile Fasciola hepatica Supports Growth and Progression towards the Adult Phenotype In Vitro.Semantic proximity Read

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease.Semantic proximity Read

Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin.Semantic proximity Read

<i>In silico</i> analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodesSemantic proximity Read