Article
Calmodulin disruption impacts growth and motility in juvenile liver fluke.
Parasites & vectors - 27 Jan 2016
McCammick Erin M, McVeigh Paul, McCusker Paul, Timson David J, Morphew Russell M, Brophy Peter M, Marks Nikki J, Mousley Angela, Maule Aaron G
Abstract excerpt
BACKGROUND: Deficiencies in effective flukicide options and growing issues with drug resistance make current strategies for liver fluke control unsustainable, thereby promoting the need to identify and validate new control targets in Fasciola spp. parasites. Calmodulins (CaMs) are small calcium-sensing proteins with ubiquitous expression in all eukaryotic organisms and generally use fluctuations in intracellular...
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