Article

Environmentally relevant depleted uranium exposure damages mitochondria, decreases cytosolic reductive capacity, and increases global DNA damage accumulation through a ROS-independent mechanism involving <i>slingshot protein phosphatase 1b</i> enrichment

2026-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Depleted uranium (DU) is an environmental contaminant with a 30 µg/L (ppb; parts per billion) EPA maximum contaminant level (MCL) for drinking water. The mining of uranium and use of DU in modern weapons underly human exposure that disproportionally impacts military and tribal communities in the United States. Uranium’s radiotoxic characteristics are understood, but its chemical hazards much les...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 858c278d-e2d1-51ae-b3d9-51769f3dc6e5
DOI: 10.64898/2026.07.02.736169

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Environmentally relevant depleted uranium exposure damages mitochondria, decreases cytosolic reductive capacity, and increases global DNA damage accumulation through a ROS-independent mechanism involving <i>slingshot protein phosphatase 1b</i> enrichmentDOI 10.64898/2026.07.02.736169Read

Arsenic impairs <i>Drosophila</i> neural stem cell mitotic progression and sleep behavior in a tauopathy modelSemantic proximity Read

Aged nanoplastics reprogram the ER stress-autophagy crosstalk: A mechanistic gateway to skeletal malformations in zebrafishSemantic proximity Read

A systems biology approach reveals neuronal and muscle developmental defects after chronic exposure to ionising radiation in zebrafishSemantic proximity Read

Phthalate Exposure Induces Inflammatory Signaling and Suppresses Mitochondrial Function in Marine Mammal and Human CellsSemantic proximity Read

Modeling Chronic Arsenic Toxicity in Drosophila melanogaster: Insights into Oxidative Stress, Neurotoxicity, and CarcinogenesisSemantic proximity Read

Thallium-induced neurocardiotoxicity in zebrafish: Protective role of adaptive UPR and DNA repairSemantic proximity Read

Sodium arsenite altered the parameters of oxidative stress and induced carcinogenesis and neurotoxicity in Canton-S Drosophila melanogasterSemantic proximity Read

Transcriptomic data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and uranyl nitrate.Semantic proximity Read

Distribution of Soluble Uranium in the Nuclear Cell Compartment at Subtoxic ConcentrationsSemantic proximity Read

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in <i>Caenorhabditis elegans</i>Semantic proximity Read

Swimming Into View: Zebrafish Uncover Targets, Mechanisms, and Therapies for Cadmium ToxicitySemantic proximity Read

The Role of Heavy Metals in the Biology of Female CancersSemantic proximity Read