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Aged nanoplastics reprogram the ER stress-autophagy crosstalk: A mechanistic gateway to skeletal malformations in zebrafish

15 Aug 2025

Abstract excerpt

Micro(nano)plastics (MNPs) are pervasive in aquatic environments, with aged MNPs being the predominant form due to environmental weathering. However, their developmental toxicity, particularly regarding skeletal formation, remains poorly understood. In this study, aged polystyrene nanoplastics (PSNPs) were prepared via 48-hour UV irradiation and compared with pristine PSNPs in zebrafish embryo exposures starting...

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PMID: 40850273
DOI: 10.1016/j.aquatox.2025.107542

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